Intelligent Medical Imaging Systems for Rapid Real-Time Diagnosis: Deep Learning, Edge AI, Hardware Acceleration, and Healthcare Intelligence
DOI:
https://doi.org/10.55578/amsr.2605.008Keywords:
Deep learning, Explainable AI, Hardware acceleration, Low-latency diagnosis, Medical image analysiAbstract
The rapid evolution of Artificial Intelligence (AI) has transformed medical imaging into an intelligent and data-driven clinical decision-support ecosystem. The growing demand for accurate, low-latency, scalable, and interpretable diagnostics has accelerated the integration of deep learning, Edge AI, and hardware acceleration in healthcare systems. Recent developments in intelligent medical imaging systems for real-time clinical diagnosis are examined in this article. The systematic review was conducted using peer-reviewed literature retrieved from IEEE Xplore, PubMed, Scopus, Web of Science, and ScienceDirect, covering studies published from 2020 to April 2026. 4,912 articles were screened, with 52 high-quality studies included for final synthesis. The review focuses on convolutional neural networks, federated learning, explainable AI, transformer-based architectures, multimodal imaging, and hardware accelerators, including Application-Specific Integrated Circuits (ASICs), Field-Programmable Gate Arrays (FPGAs), Tensor Processing Units (TPUs), Graphics Processing Units (GPUs), and neuromorphic processors. Findings indicate substantial improvements in diagnostic accuracy, computational efficiency, scalability, and low-latency inference across cardiology, oncology, pathology, radiology, and ophthalmology. Main challenges include heterogeneous data sources, high energy demands, limited clinical validation, and lack of interpretability, privacy concerns, interoperability issues, and regulatory barriers. Emerging directions include digital twins, lightweight AI, multimodal foundation models, sustainable edge intelligence, and privacy-preserving federated ecosystems, highlighting the transformative potential of intelligent medical imaging in precision healthcare.
References
[1] Ahmad, Z., Rahim, S., Zubair, M., & Abdul-Ghafar, J. (2021). Artificial intelligence (AI) in medicine, current applications and future role with special emphasis on its potential and promise in pathology. International Journal of Pathology and Clinical Research, *7*(1), 1-11. https://doi.org/10.23937/2469-5807/1510138
[2] Wang, J., Zhu, H., Wang, S. H., & Zhang, Y. D. (2021). A review of deep learning on medical image analysis. Mobile Networks and Applications, *26*(1), 351-380. https://doi.org/10.1007/s11036-020-01672-9
[3] Alzubaidi, L., Zhang, J., Humaidi, A. J., Al-Dujaili, A., Duan, Y., Al-Shamma, O., … & Farhan, L. (2021). Review of deep learning: Concepts, CNN architectures, challenges, applications, future directions. Journal of Big Data, *8*(1), 53. https://doi.org/10.1186/s40537-021-00444-8
[4] Fu, Y., Lei, Y., Wang, T., Curran, W. J., Liu, T., & Yang, X. (2020). Deep learning in medical image registration: A review. Physics in Medicine & Biology, *65*(20), 20TR01. https://doi.org/10.1088/1361-6560/ab843e
[5] Minaee, S., Boykov, Y., Porikli, F., Plaza, A., Kehtarnavaz, N., & Terzopoulos, D. (2021). Image segmentation using deep learning: A survey. IEEE Transactions on Pattern Analysis and Machine Intelligence, *44*(7), 3523-3542. https://doi.org/10.1109/TPAMI.2021.3059968
[6] Zhou, S. K., Greenspan, H., & Shen, D. (2021). Deep learning for medical image analysis. Academic Press. https://doi.org/10.1016/C2019-0-03742-9
[7] Hayyolalam, V., Aloqaily, M., Özkasap, Ö., & Guizani, M. (2021). Edge-assisted solutions for IoT-based connected healthcare systems: A literature review. IEEE Internet of Things Journal, *9*(12), 9419-9443. https://doi.org/10.1109/JIOT.2021.3128787
[8] Wang, K., Kong, S., Chen, X., & Zhao, M. (2024). Edge computing empowered smart healthcare: monitoring and diagnosis with deep learning methods. Journal of Grid Computing, *22*(1), 30.
[9] Gill, S. S., Golec, M., Hu, J., Xu, M., Du, J., Wu, H., … & Uhlig, S. (2025). Edge AI: A taxonomy, systematic review and future directions. Cluster Computing, *28*(1), 18. https://doi.org/10.1007/s10586-024-04785-2
[10] Deng, C., Fang, X., Wang, X., & Law, K. (2022). Software orchestrated and hardware accelerated artificial intelligence: Toward low latency edge computing. IEEE Wireless Communications, *29*(4), 110-117. https://doi.org/10.1109/MWC.001.2100483
[11] Ghani, A., Aina, A., & Hwang See, C. (2024). An optimised CNN hardware accelerator applicable to IoT end nodes for disruptive healthcare. IoT, *5*(4), 901-921. https://doi.org/10.3390/iot5040045
[12] Liu, Z., Bi, Z., Liang, C. X., Song, J., Wang, T., Zhang, Y., … & Song, X. (2025). Hardware accelerated foundations for multimodal medical AI systems: A comprehensive survey. arXiv Preprint. https://doi.org/10.48550/arXiv.2502.12345
[13] Prasad, N. S., & Sundar, S. (2025). Comprehensive review on the exploitation of advanced memory optimization strategies to improve performance for convolutional and spiking neural networks in medical imaging using hardware accelerators. IEEE Access.
[14] Wang, T., Guo, J., Zhang, B., Yang, G., & Li, D. (2025). Deploying AI on edge: Advancement and challenges in edge intelligence. Mathematics, *13*(11), 1878. https://doi.org/10.3390/math13111878
[15] Corral, J. M. R., Civit-Masot, J., Luna-Perejón, F., Díaz-Cano, I., Morgado-Estévez, A., & Domínguez-Morales, M. (2024). Energy efficiency in edge TPU vs. embedded GPU for computer-aided medical imaging segmentation and classification. Engineering Applications of Artificial Intelligence, *127*, 107298. https://doi.org/10.1016/j.engappai.2024.107298
[16] Li, M., Jiang, Y., Zhang, Y., & Zhu, H. (2023). Medical image analysis using deep learning algorithms. Frontiers in Public Health, *11*, 1273253. https://doi.org/10.3389/fpubh.2023.1273253
[17] Sadeghi, A., Sadeghi, M., Fakhar, M., Zakariaei, Z., Sadeghi, M., & Bastani, R. (2024b). A deep learning-based model for detecting Leishmania amastigotes in microscopic slides: A new approach to telemedicine. BMC Infectious Diseases, *24*(1), 551. https://doi.org/10.1186/s12879-024-08551
[18] Albahri, A. S., Duhaim, A. M., Fadhel, M. A., Alnoor, A., Baqer, N. S., Alzubaidi, L., … & Deveci, M. (2023). A systematic review of trustworthy and explainable artificial intelligence in healthcare: Assessment of quality, bias risk, and data fusion. Information Fusion, *96*, 156-191. https://doi.org/10.1016/j.inffus.2023.03.008
[19] He, Q., Xi, Z., Feng, Z., Teng, Y., Ma, L., Cai, Y., & Yu, K. (2024). Telemedicine monitoring system based on fog/edge computing: A survey. IEEE Transactions on Services Computing, *18*(1), 479-498. https://doi.org/10.1109/TSC.2024.3362323
[20] Putra, K. T., Arrayyan, A. Z., Hayati, N., Damarjati, C., Bakar, A., & Chen, H. C. (2024). A review on the application of Internet of Medical Things in wearable personal health monitoring: A cloud-edge artificial intelligence approach. IEEE Access, *12*, 21437-21452. https://doi.org/10.1109/ACCESS.2024.3365402
[21] Xu, Y., Khan, T. M., Song, Y., et al. (2025). Edge deep learning in computer vision and medical diagnostics: A comprehensive survey. Artificial Intelligence Review, *58*, 93. https://doi.org/10.1007/s10462-024-11033-5
[22] Shen, D., Wu, G., & Suk, H. I. (2017). Deep learning in medical image analysis. Annual Review of Biomedical Engineering, *19*, 221-248. https://doi.org/10.1146/annurev-bioeng-071516-044442
[23] Tsuneki, M. (2022). Deep learning models in medical image analysis. Journal of Oral Biosciences, *64*(3), 312-320. https://doi.org/10.1016/j.job.2022.04.001
[24] Gao, X., He, P., Zhou, Y., & Qin, X. (2024). A smart healthcare system for remote areas based on the edge-cloud continuum. Electronics, *13*(21), 4152. https://doi.org/10.3390/electronics13214152
[25] Siripurapu, S., Darimireddy, N. K., Chehri, A., Sridhar, B., & Paramkusam, A. V. (2023). Technological advancements and elucidation gadgets for healthcare applications: An exhaustive methodological review—Part I (AI, big data, blockchain, open-source technologies, and cloud computing). Electronics, *12*(3), 750. https://doi.org/10.3390/electronics12030750
[26] Bourechak, A., Zedadra, O., Kouahla, M. N., Guerrieri, A., Seridi, H., & Fortino, G. (2023). At the confluence of artificial intelligence and edge computing in IoT-based applications: A review and new perspectives. Sensors, *23*(3), 1639. https://doi.org/10.3390/s23031639
[27] Alcaín, E., Fernández, P. R., Nieto, R., MonteAprilor, A. S., Vilas, J., Galiana-Bordera, A., … & Torrado-Carvajal, A. (2021). Hardware architectures for real-time medical imaging. Electronics, *10*(24), 3118. https://doi.org/10.3390/electronics10243118
[28] Al Habsi, O., Sali, S. M., Meribout, A., Meribout, M., Almazrouei, S., & Seghier, M. (2025). Hardware acceleration in portable MRIs: State of the art and future prospects. IEEE Access. https://doi.org/10.1109/ACCESS.2025.3624072
[29] Rieke, N., Hancox, J., Li, W., Milletari, F., Roth, H. R., Albarqouni, S., … Cardoso, M. J. (2020). The future of digital health with federated learning. npj Digital Medicine, *3*(1), 119. https://doi.org/10.1038/s41746-020-00323-1
[30] Mashmool, A., Delzanno, G., Saadatfar, H., Ahmad, A., Koschke, R., Alizadehsani, R., … & D’Agostino, D. (2026). Edge computing in healthcare using machine learning: A systematic literature review. Wiley Interdisciplinary Reviews: Data Mining and Knowledge Discovery, *16*(1), e70069. https://doi.org/10.1002/widm.70069
[31] Alqudah, A. M., & Moussavi, Z. (2025). A review of deep learning for biomedical signals: Current applications, advancements, future prospects, interpretation, and challenges. Computers, Materials & Continua, *83*(3). https://doi.org/10.32604/cmc.2025.062099
[32] Rahman, M. A., Hossain, M. S., Alrajeh, N. A., & Guizani, N. (2020). B5G and explainable deep learning-assisted healthcare vertical at the edge: COVID-19 perspective. IEEE Network, *34*(4), 98-105.
[33] Younas, M. I., Iqbal, M. J., Aziz, A., & Sodhro, A. H. (2023). Toward QoS monitoring in IoT edge devices driven healthcare: A systematic literature review. Sensors, *23*(21), 8885. https://doi.org/10.3390/s23218885
[34] Gao, X., He, P., Zhou, Y., & Qin, X. (2024). Artificial intelligence applications in smart healthcare: A survey. Future Internet, *16*(9), 308. [无DOI]
[35] Jamshidi, M., Moztarzadeh, O., Jamshidi, A., Abdelgawad, A., El-Baz, A. S., & Hauer, L. (2023). Future of drug discovery: The synergy of edge computing, internet of medical things, and deep learning. Future Internet, *15*(4), 142. https://doi.org/10.3390/fi15040142
[36] Chen, J., Mei, J., Li, X., Lu, Y., Yu, Q., Wei, Q., … & Zhou, Y. (2024). TransUNet: Rethinking the U-Net architecture design for medical image segmentation through the lens of transformers. Medical Image Analysis, *97*, 103280. https://doi.org/10.1016/j.media.2024.103280
[37] Sahiner, B., Pezeshk, A., Hadjiiski, L. M., Wang, X., Drukker, K., Cha, K. H., … & Giger, M. L. (2019). Deep learning in medical imaging and radiation therapy. Medical Physics, *46*(1), e1-e36. https://doi.org/10.1002/mp.13264
[38] Gaikwad, N. B., Khare, S. K., Mendhe, D., Mir, H., Kosta, S., & Acharya, U. R. (2025). FPGA SoC implementation of adaptive deep neural network based multimodal edge intelligence for internet of medical things. IEEE Access.
[39] Sadeghi, A., Sadeghi, M., Sharifpour, A., Fakhar, M., Zakariaei, Z., Sadeghi, M., … Hajati, F. (2024a). Potential diagnostic application of a novel deep learning-based approach for COVID-19. Scientific Reports, *14*(1), 280. https://doi.org/10.1038/s41598-024-00280
[40] Aryendu, I., & Wang, Y. (2024). Raider: Rapid AI diagnosis at edge using ensemble models for radiology. IEEE Access, *12*, 115546-115560.
[41] Makina, H., & Ben Letaifa, A. (2023). Bringing intelligence to edge/fog in Internet of Things-based healthcare applications: Machine learning/deep learning-based use cases. International Journal of Communication Systems, *36*(9), e5484. https://doi.org/10.1002/dac.5484
[42] Manduva, V. C. (2024). Scalable AI: Leveraging cloud and edge computing for real-time analytics. International Journal of Scientific Research and Management (IJSRM), *12*(11), 1788-1813.
[43] Thota, R. C. (2024). Optimizing edge computing and AI for low-latency cloud workloads. International Journal of Science and Research Archive, *13*(1), 3484-3500. https://doi.org/10.30574/ijsra.2024.13.1.1987
[44] Vishweshwara, A., & Ramya, R. (2026). Transforming telemedicine: Reducing latency through edge computing and 5G—A review. Biomedical Materials & Devices, *4*(2), 1161-1174. https://doi.org/10.1007/s44174-026-00231-8
[45] Alshuhail, A., Alshahrani, A., Mahgoub, H., Ghaleb, M., Darem, A. A., Aljehane, N. O., … & Alzahrani, F. (2025). Machine edge-aware IoT framework for real-time health monitoring: Sensor fusion and AI-driven emergency response in decentralized networks. Alexandria Engineering Journal, *129*, 1349-1361. https://doi.org/10.1016/j.aej.2025.1349-1361
[46] Batool, I. (2025). Real-time health monitoring using 5G networks: Deep learning-based architecture for remote patient care. JMIRx Med, *6*, e70906. https://doi.org/10.2196/70906
[47] Ranganathan, R., Annamalai, A., Ruban, S., Mythili, S., Shuriya, B., & Balajishanmugam, V. (2025). Sustainable AI for medical imaging: A federated, edge-based approach to chest X-ray triage. In 2025 International Conference on Modern Sustainable Systems (CMSS) (pp. 945-952). IEEE.
[48] Zhu, B., Shin, U., & Shoaran, M. (2021). Closed-loop neural prostheses with on-chip intelligence: A review and a low-latency machine learning model for brain state detection. IEEE Transactions on Biomedical Circuits and Systems, *15*(5), 877-897.
[49] Shaukat, F., Parwez, K., Ashraf, Z., Alhabeeb, A., Alotabi, F. A., & Alnfiai, M. M. (2026). MobileNet-Lite-Health: A sustainable edge AI framework for medical image classification and carbon-aware computing. IEEE Access. https://doi.org/10.1109/ACCESS.2026.000000
[50] Badawy, W. (2026). Low-power AI and signal processing for the edge: Tools, techniques, and applications. Neural Computing and Applications, *38*(9), 346. https://doi.org/10.1007/s00521-026-11936-0
[51] Benjumea, A., Ropero, J., Rivera-Romero, O., Dorronzoro-Zubiete, E., & Carrasco, A. (2020). Assessment of mobile monitoring and wearable sensors for continuous management of COVID-19 and chronic diseases. Sensors, *20*(18), 5202. https://doi.org/10.3390/s20185202
[52] Mulo, J., Liang, H., Qian, M., Biswas, M., Rawal, B., Guo, Y., & Yu, W. (2025). Navigating challenges and harnessing opportunities: Deep learning applications in Internet of Medical Things. Future Internet, *17*(3), 107. https://doi.org/10.3390/fi17030107
[53] Wang, S., Summers, R. M., & Yao, J. (2021). Machine learning and radiology. Medical Image Analysis, *71*, 102017. https://doi.org/10.1016/j.media.2021.102017
[54] Letaief, K. B., Shi, Y., Lu, J., & Lu, J. (2021). Edge artificial intelligence for 6G: Vision, enabling technologies, and applications. IEEE Journal on Selected Areas in Communications, *40*(1), 5-36.
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