Protocatechualdehyde in Medicine: What We Know and What Lies Ahead
DOI:
https://doi.org/10.55578/amsr.2601.001Keywords:
Protocatechualdehyde (PubChem CID: 8768), Anti-oxidant, Anti-inflammatory, Traditional Chinese Medicine, Salvia miltiorrhizaAbstract
Background: Protocatechualdehyde (PCA) is a naturally-occurring phenolic aldehyde commonly found in many plants and plant-based products. PCA has many possible health benefits. It has shown promising anti-oxidant, anti-inflammatory, anti-bacterial and anti-carcinogenic traits.
Objective: In this study, we aim to explore PCA’s potential uses as a therapeutic agent and recommend future research directions.
Methods: PubMed was searched in November 2024. Every article containing “protocatechualdehyde” or “protocatechuic aldehyde” in title or abstract were looked into and relevant studies selected.
Results: PCA has the potential to be effective on a variety of disease. The top five most researched on conditions are: wound healing, atherosclerosis, myocardial ischemia, cerebrovascular disease, Parkinson’s disease. Articles mainly focus on cardiovascular, central nervous and urinary systems. Wound-sealant hydrogels containing PCA as a topical agent are an area of focus as well. anti-oxidant, anti-inflammatory, and anti-bacterial properties of PCA appear to give PCA its therapeutic potential. PCA can impact many intracellular pathways including Wnt/β-catenin signaling pathway and induce antiapoptotic proteins like B-cell lymphoma protein.
Discussion: In conclusion, studies regarding PCA’s therapeutic use have been diverse, but dispersed, and in a few instances contradictory. PCA can have a positive impact on a range of illnesses and conditions in vitro and in vivo. It appears that PCA owes its therapeutic features to its strong anti-oxidant, anti-inflammatory, and anti-bacterial effects. However, Current research lacks in showing PCA’s possible systemic effects and interaction with human body. PCA can become a potent pharmacological agent in the future, but still has a long journey ahead.
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